Universal linkers for signal amplification in auto-ligating probes
نویسندگان
چکیده
منابع مشابه
Signal amplification of padlock probes by rolling circle replication.
Circularizing oligonucleotide probes (padlock probes) have the potential to detect sets of gene sequences with high specificity and excellent selectivity for sequence variants, but sensitivity of detection has been limiting. By using a rolling circle replication (RCR) mechanism, circularized but not unreacted probes can yield a powerful signal amplification. We demonstrate here that in order fo...
متن کاملAdaptive Signal Detection in Auto-Regressive Interference with Gaussian Spectrum
A detector for the case of a radar target with known Doppler and unknown complex amplitude in complex Gaussian noise with unknown parameters has been derived. The detector assumes that the noise is an Auto-Regressive (AR) process with Gaussian autocorrelation function which is a suitable model for ground clutter in most scenarios involving airborne radars. The detector estimates the unknown...
متن کاملA universal biosensor for multiplex DNA detection based on hairpin probe assisted cascade signal amplification.
A hairpin DNA probe mediated cascade signal amplification method was developed for visual and rapid DNA analysis with a detection limit of 100 aM. The implementation of tag/anti-tag DNA and gold nanoparticle reporters permits a universal platform for multiplex genotyping without instrumentation.
متن کاملNoisy signal amplification in ultrasensitive signal transduction.
Because intracellular processes are inherently noisy, stochastic reactions process noisy signals in cellular signal transduction. One essential feature of biological signal transduction systems is the amplification of small changes in input signals. However, small random changes in the input signals could also be amplified, and the transduction reaction can also generate noise. Here, we show th...
متن کاملComparing signal amplification of thiocyanated Gold nanoparticles in the presence of different ions
Detecting is the most important section in all kinds of sensors. In this regard, the amplification of surface plasmon resonance intensity of gold colloids nanoparticles (GNPs) was studied in the presence of several ions. GNPs were synthesized and then capped by thiocyanate and characterized via DLS and TEM image. In the next step the effect of different concentrations of ions such as iron, copp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Symposium Series
سال: 2005
ISSN: 1746-8272,0261-3166
DOI: 10.1093/nass/49.1.37